منابع مشابه
Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors.
UNLABELLED Neurofibromatosis type 1 (NF1) is a neurogenetic disorder. Individuals with NF1 may develop a variety of benign and malignant tumors of which peripheral nerve sheath tumors represent the most frequent entity. Plexiform neurofibromas may demonstrate a locally destructive growth pattern, may cause severe symptoms and may undergo malignant transformation into malignant peripheral nerve ...
متن کاملGlomus tumors in individuals with neurofibromatosis type 1.
BACKGROUND Glomus tumors have recently been reported in individuals with the neurofibromatosis type 1 (NF1) cancer disposition syndrome. We compare the clinical and molecular features of these painful hamartomas in a series of sporadic and NF1-associated cases. OBJECTIVE We sought to evaluate the association of NF1 with glomus tumors and to compare NF1-associated glomus tumors with sporadic g...
متن کاملSomatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors.
Neurofibromatosis type 1 is an autosomal dominantly inherited disease predisposing to a multitude of tumors, most characteristically benign plexiform neurofibromas and diffuse cutaneous neurofibromas. We investigated the presence and distribution of somatic mitochondrial DNA (mtDNA) mutations in neurofibromas and in nontumor tissue of neurofibromatosis type 1 patients. MtDNA alterations in the ...
متن کاملMalignant Triton Tumors in Sisters with Clinical Neurofibromatosis Type 1
Malignant triton tumors (MTTs) are rare and aggressive sarcomas categorized as a subgroup of malignant peripheral nerve sheath tumors (MPNSTs). MTTs arise from Schwann cells of peripheral nerves or existing neurofibromas and have elements of rhabdomyoblastic differentiation. We report the occurrence of MTTs in two sisters. The first patient is a 36-year-old female who presented with left sided ...
متن کاملThe association between hypotonia and brain tumors in children with neurofibromatosis type 1.
Children with the neurofibromatosis type 1 (NF1) inherited tumor predisposition syndrome are at risk for the development of brain tumors. In addition, children with neurofibromatosis type 1 often exhibit low tone (hypotonia). In this study, the authors explored the hypothesis that hypotonia could be a clinical indicator of glioma in children with neurofibromatosis type 1. A total of 56 children...
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ژورنال
عنوان ژورنال: Neuro-Oncology Advances
سال: 2019
ISSN: 2632-2498
DOI: 10.1093/noajnl/vdz040